There are many reasons for incomplete liquefaction of sperm, such as considerations related to low room temperature, semen storage time is short and other in vitro factors, generally do not need special treatment. It is also considered to be related to prostatitis, seminal vesiculitis, varicocele, etc. Patients can follow the doctor’s prescription of medication or surgical treatment. 1. In vitro factors: Incomplete liquefaction of spermatozoa can be caused when the spermatozoa are stored in an environment with low room temperature or for a short period of time. If there are no other abnormalities, treatment is usually not necessary, and incomplete sperm liquefaction can be improved when the environment outside the body is changed. 2. Prostatitis: If it is clear that prostatitis is the cause of the problem, according to the results of bacterial culture and drug sensitivity test, follow the doctor’s instructions with penicillin, levofloxacin, azithromycin and other antibacterial drugs. Those with pain or abnormal bowel movements can be treated with oral α-blockers, such as tamsulosin hydrochloride and doxazosin, as prescribed by the doctor. Avoid eating spicy and irritating food. 3. Seminal vesiculitis: patients can also choose sensitive antibiotic treatment as prescribed by the doctor, such as cefuroxime, levofloxacin and so on. Secondary abscess can be prescribed open surgery incision and drainage, some patients can also be interventional therapy. 4. Varicose veins: Varicose veins cause incomplete liquefaction of spermatozoa, can be considered for laparoscopic spermatic vein ligation, spermatic vein embolization and other surgical treatments. After surgery, the incomplete liquefaction of sperm can be improved. It is recommended that people with incomplete liquefaction of sperm should consult a doctor for examination, so as to clarify the cause of the disease and then follow the doctor’s instructions for treatment, and should not use drugs indiscriminately.