There is no special medicine for knee osteomalacia. It is often triggered by degenerative changes, trauma and other factors, and can be treated with local topical medicines such as Nanxing Pain Relief Cream and oral medicines such as diclofenac sodium. 1. Local topical medicine: when the joint pain, generally can be used to relieve the local soft tissue pain, such as pain relief cream, ibuprofen cream. There may be skin allergy and other adverse reactions to the topical application of pain relief cream and ibuprofen cream. 2. Oral medication: knee osteomalacia can be used diclofenac sodium, celecoxib capsules and other anti-inflammatory and analgesic drugs, to relieve pain symptoms; oral chondroitin sulfate, which can increase cartilage production and cell metabolism. Diclofenac sodium, celecoxib, chondroitin sulfate medication may be gastrointestinal discomfort and other adverse reactions. 3. Joint cavity injection of drugs: generally can be used to inject sodium vitrate, compound betamethasone, etc. Injection of sodium vitrate can lubricate the local joints and promote cartilage repair; compound betamethasone can alleviate joint pain symptoms, anti-inflammatory and so on. Dexamethasone may have adverse reactions such as allergic symptoms. The appearance of knee osteoarthritis, it is recommended to promptly go to the regular hospital for consultation and active treatment.