The chances of turning negative are small, and generally will not turn negative, because the drugs can not completely remove the virus, and the small second sun is located in the middle of the state of small triple and large triple, and will also be transformed with the disease. Generally speaking, small two-positive, small three-positive and large three-positive are all changes in the course of viral hepatitis B. Small two-positive refers to the hepatitis B surface antigen and core antibody are positive, and the other three are negative, and is located in the middle of small three-positive and large three-positive, which may change to large three-positive with the aggravation of the condition, or may change to small three-positive. Moreover, from the viewpoint of the current anti-virus treatment, anti-hepatitis B virus drugs cannot completely remove the hepatitis B virus from the body. If we only rely on our own immunity to clear the hepatitis B virus, the natural chance of negative transformation is low, so we usually have to apply antiviral drugs for a long time. Therefore, if you have a small bi-positive test, the chance of conversion is very low, and you still need to apply antiviral drugs persistently, unless there are new drugs that can cure the hepatitis B virus in the future, then there will be a hope of converting to a negative condition.