Epithelial scabies nodules, refers to scabies in severe cases in the skin thin tender place appeared soybean or green beans big texture slightly hard brownish-red nodules, you can take tretinoin neomycin cream and other medications, intradermal injections and cryotherapy and so on. 1. Topical medication: Scabies nodules can be treated with tar gel applied nightly for 2 to 3 weeks, or topical Trichostatin cream. 2. Intradermal injection: Intradermal injection of the glucocorticoid tretinoin into the skin lesions also has a good therapeutic effect. 3. Cryotherapy: rapid freezing of tissues, the temperature is reduced to below -196℃, the intracellular and extracellular tissue fluid forms ice crystals, and the cell structure is destroyed. After freezing followed by cell dehydration, tissue ischemic infarction, nutritional deficiencies, and ultimately lead to epididymal scabies nodules necrosis. Epididymal scabies nodules, there may be other treatments, it is recommended to go to the hospital, improve the examination to determine the cause of the disease, and then give targeted treatment or treatment. All of the above medications should be used under the guidance of a doctor.