Positive core antibody and surface antigen are both indicators of hepatitis B. The difference lies in the significance they represent, and once hepatitis B is detected, it is necessary to seek medical treatment in a timely manner. Positive core antibody to hepatitis B virus usually means that the patient is in the early stage of hepatitis B virus infection or has been infected with hepatitis B virus in the past, but at this time the virus has already been cleared, and since the core antibody itself has no protective effect, there is still a possibility of re-infection. Hepatitis B surface antibody is a protective antibody, indicating immunity to the hepatitis B virus. Hepatitis B virus surface antigen is positive, which indicates that the person is infected with hepatitis B virus and is contagious, and the diagnosis of hepatitis B disease should be made through further systematic and comprehensive examination.