Dry syndrome (Sjögren’s syndrome, SS) is a chronic autoimmune disease characterized by invasion of the exocrine glands, and is also called autoimmune exocrine gland epithelial cell inflammation, or autoimmune exocrine adenopathy, because its inflammatory response is mainly manifested in the epithelial cells of the exocrine glands. The most common symptom is dryness of the mouth and eyes due to damage to salivary glands and lacrimal glands, but the disease often involves multi-organ and multi-system lesions, and can develop into lymphoma in severe cases. Dryness syndrome occurs most frequently in autoimmune rheumatic diseases and often overlaps with other autoimmune diseases. The disease is more than 90% female, and the age of onset is mostly between 40 and 50 years. The etiology may be related to genetic, immune, endocrine and viral infections. The pathological changes are mainly progressive destruction of glandular tissue infiltrated by lymphocytes and plasma cells, resulting in reduced saliva and tear secretion and dry mouth and eye symptoms. According to its clinical manifestations, it belongs to the category of dryness evidence and dryness paralysis in Chinese medicine. Dry syndrome belongs to the category of dryness paralysis in Chinese medicine. The root of its pathogenesis is dryness. In Su Wen Yin Yang Ying Xiang Da Lun (《素問陰陽應象大论篇》), there is that dryness prevails, and in Liu Wan Su (金代刘完素) in Su Wen Xuan Ji Yuan Yi Yuan Sickness Style (《素問玄機原病式》), there is that all astringent dryness and dryness, dryness and chapping are all dryness. This is a general overview of the pathological characteristics and clinical manifestations of dryness. Qing Yu Jiayan believes that the disease of dryness should be distinguished from internal and external injuries, and suggests that internal dryness and external dryness should be distinguished. In Suwen Xuanming Five Qi Theory, it is said that the heart is sweat, lung is snot, liver is tears, spleen is saliva, kidney is saliva, these are the five fluids, which are transformed by the organs. Dryness syndrome has an insidious onset, long duration and wide range of damage, without significant seasonal onset, and is related to internal injuries of the internal organs. It is pointed out in the “Treatment of Classical Evidence” that dryness has external and internal causes. Because of the external, the weather is stern and dryness wins, or wind-heat to the qi part, then the fluid does not rise because of the internal, essence and blood to take away and dryness is born, or bait to help Yang fire, then the source of chemistry is dried up. The “Introduction to Medicine” also says: dryness is divided into internal and external, the external cause of the time when the Yang Ming dryness, the internal cause of the seven feelings of fire dryness, or loss of stool, the loss of fluid, or gold and stone dry blood, or room exhaustion of essence, or hunger, fatigue and loss of stomach can be biased to help the fire evil, blood scorching. It can be seen that the cause of this disease because of congenital deficiency of endowment, deficiency of liver and kidney yin essence, deficiency of essence and blood, loss of yin and fluid, can not moisten the internal organs, limbs and bones; or because of emotional and mental disorders, liver depression into fire, fire and heat injures the fluid into dryness; also because of repeated feelings of dryness or excessive consumption of dryness and heat drugs, the accumulation of heat breeding poison, burning fluid, dryness. When dryness is strong, it becomes poisonous for a long time and burns Yin and Jin, and the clear orifices are not moistened and nourished, so that Yin and Blood are not sufficient for a long time, and Blood flow is not smooth, and stasis of Blood blocks the ligaments, involving the skin and mucous membrane, muscles and joints. Jin injury into dryness, dryness and injury to Jin, mutual cause and effect, so the disease is long-lasting, lingering difficult to cure. 1.Yin deficiency produces dryness This disease is more common in women above middle age. The cause is the congenital deficiency of endowment, the five organs are weak, liver and kidney yin deficiency; or old age yin gradually decay, or late fever, or a long illness, plus the woman more pregnancy and childbirth breast suffering, yin and blood loss, fluid depletion, the mouth and eyes clear orifice loss of moistening, viscera tissue loss of its moistening and dry evidence. 2, emotional and mental factors “Gu Song Yuan Medical Mirror” has a cloud of labor and weariness injury to the spleen, is the spleen of the Yin part of the injury is mostly. Thinking about labor and tiredness injury to the spleen, Ying Yin damage, the body’s normal fluid deficiency, it is difficult to continue, it is easy to develop for dryness. The spleen is the essence of the latter, the main transporter of water and liquid. As Tang Rongchuan pointed out in his treatise on the disease mechanism of the internal organs, the spleen is called wet earth, and wet earth nourishes everything, and the spleen moistens the internal organs. However, “Suwen angry through the day” said: Yin’s birth, the original in the five flavors, Yin’s five palaces, injury in the five flavors. If you do not eat well or addicted to spices, sorghum, thick-tasting products, damage to the spleen and stomach. If the spleen and stomach are weak, spleen yin loss will be lack of fluid source, can not be on the glory of the mouth, nose, eyes, and see the mouth, nose, eyes dry; can not irrigate the limbs meridians, muscles and skin, see dry skin, muscle lack of Ze, muscle joint pain; spleen yin can not nourish the internal organs, visible dysfunction of the internal organs. 4, wind, heat and dryness invasion of Yin deficiency, coupled with external warmth and dryness, heat, burning fluid; or gold and stone medicine poison, accumulated heat brew poison, burning fluid refining liquefaction dryness and cause the disease. 5, blood stasis blockage Jin and blood homologation. Jin and blood are closely related to each other. Dryness hurts yin, qi and yin are both injured, and the blood transport is astringent due to the low amount of fluid and weak qi, resulting in internal stasis of blood. Stasis of blood within the stagnation, no way to seep outside the veins as Jin, and over time aggravate the dryness of the skin and muscles. The stagnation of blood vessels and veins leads to the symptoms of muscles and joints. The basic pathogenesis of this disease is the deficiency of Yin, blood and fluid in the body, which results in the loss of moistening of the skin, hair and nine orifices. Internally, the tendons, joints and muscles are not nourished, and there are abnormal manifestations such as exhaustion and dryness, yin deficiency and fire heat, stasis and blood paralysis. The disease is prolonged for a long time and involves multiple systems of organs and tissues. Therefore, Yin deficiency is the main cause, and stasis, paralysis and dryness are the symptoms. The essence of the disease is deficiency of qi and yin, which is closely related to the internal organs of lung, spleen, liver and kidney. The disease is located in the mouth, eyes, nose, pharynx and other clear orifices. The nature of the disease is deficient in nature and real in symptoms, with Yin deficiency in the lung, spleen, liver, kidney and other internal organs as the main cause and dryness, heat and blood stasis as the symptoms. At the beginning of the disease, the yin and yang ying and gui are not regulated, the qi is not elevated, the flow of fluid is obstructed, the clear and turbid is disrupted, the orifices are not moistened and the mouth, eyes, nose and throat are dry, the limbs, muscles and joints are sore and tired, or the wind and cold are slightly evil. The biochemical distribution of human yin and fluid depends on the qi of the five viscera, and qi stagnation and yin deficiency will result in dryness of the mouth, nose and eyes, less saliva, foreign body sensation in the eyes, or pain in the chest and dizziness. The same source of fluid and blood, deficiency of Yin, dryness of the veins and blood stagnation. Stasis and heat evaporate internally, and the true yin becomes drier. The combination of deficiency and stasis leads to dry eyes, blurred vision, dry and atrophied mucous membranes of the mouth and nose, dark eyes, swollen salivary glands, and a dry and atrophied tongue with petechiae. If Yin deficiency and dryness are hot, then dryness and stasis will fight with each other for a long time, and then dryness will become poisonous.