1.Patients with dry syndrome should develop treatment plan under the consultation of multidisciplinary doctors such as rheumatology, ophthalmology and stomatology. It is a chronic inflammatory autoimmune disease, which cannot be cured at present. The purpose of treatment is mainly to relieve the symptoms and stop the development of the disease, so as to improve the quality of life and prolong the survival period of patients. 2, multi-system damage to be symptomatic treatment. Those with dry mouth can drink moderate amounts of water, chew sugar-free gum to reduce symptoms, or take oral cypionate and other symptomatic treatment, dry eyes can apply artificial tears to reduce the symptoms of dry eyes, dry skin can apply appropriate emollients. For non-specific symptoms, such as weakness, poor sleep quality, etc., symptomatic treatment with corresponding Chinese and Western medicine can be given. 3.Secondary dry syndrome is mainly treated for the primary disease. 4. Those who have multi-system damage should be treated symptomatically and given corresponding systemic treatment at the same time: (1) For those with combined muscle and joint pain, oral treatment with non-steroidal anti-inflammatory drugs and hydroxychloroquine. (2) In cases of renal tubular acidosis combined with hypokalemia, timely potassium supplementation treatment should be given, and potassium citrate should be applied for hyperchloremic acidosis. (3) In case of concurrent neurological lesions, interstitial lung lesions, renal damage, hematologic lesions and vasculitis, glucocorticoids and/or cytotoxic drugs can be applied as appropriate, and the specific medication is similar to that for SLE. 5. Biological agents: It is now clear that abnormal activation of auto-reactive B cells is an important factor in the pathogenesis of SS, and more and more clinical studies have shown that B-cell clearance therapy with CD20 and anti-CD22 antibodies can improve SS disease. Rituximab has been shown to have good efficacy in those patients with pSS who are not well treated with conventional therapy and have severe arthritis, severe hemocytopenia, peripheral neuropathy, and associated lymphoma, but further observational studies are needed to determine whether this drug can ultimately alter the course of SS and eliminate the abnormal immune response in the SS exocrine glands. 6. Clinically, new biological agents, immunotherapy, gene therapy and Chinese medicine are used in a targeted manner according to the pathogenesis of SS, bringing hope to patients with SS who have not been cured for a long time.