When it comes to “autologous fat filler”, the survival rate of fat is the most important concern for the candidates. The inner part of the thigh is often chosen as the fat donor area because of the higher quality of fat particles there, which can increase the survival rate of the transplanted fat after surgery. However, “how to improve the survival rate of autologous fat grafting” has been a clinical challenge. In 1993, Hood et al. first introduced the concept of PRP and found that PRP is rich in platelets, with a platelet count more than three times higher than that in whole blood. Why does this occur? Platelets contain large amounts of growth factors, and when activated platelets can release large amounts of these growth factors to promote cell proliferation, collagen production, promote wound healing, induce cell division, promote epithelial cell production, neovascularization, etc. Clinical and experimental studies have also shown that PRP can promote the survival of transplanted fat. A study was conducted in which a 9:1 mixture of autologous fat tissue and PRP was transplanted for breast reconstruction, and the volume maintenance rate of the PRP mixed fat transplantation group was 69% at 1 year after surgery, compared to 39% in the fat transplantation group alone, indicating that PRP can promote the survival of transplanted fat. Why can PRP improve the survival rate of autologous fat grafting? PRP promotes the survival of transplanted fat may be related to the following aspects: 1. PRP contains a variety of growth factors, such as PDGF, EGF, PDAF and VEGF, which promote the neovascularization of the transplanted fat recipient area, thus facilitating the survival of transplanted fat; 2. PRP contains plasma nutrients that provide early nutrients for the survival of transplanted fat; 3. PRP promotes the proliferation and differentiation of fat-derived stem cell proliferation and differentiation. The discovery of PRP can be said to have further improved the survival rate of fat cells. This is why it is recommended for candidates, to add RPR appropriately when doing autologous fat fillers. The survival rate of autologous fat filler has been improved, but the risks of its surgery still exist. As we all know, the main complications of facial autologous fat grafting are sclerosis, calcification, infection necrosis, absorption, asymmetry, embolism, etc. Another more serious complication is vascular embolism. Solutions: These complications sound terrible, and standardized operation can reduce most of the risks. And the application of PRP also reduces the degree of risk of infection and resorption to some extent. For vascular embolism, it is recommended that the doctor should closely observe the injection and be highly alert to the possibility of vascular embolism when the candidate experiences pain at the injection site, skin color change, headache, and vision change.