The differences between rabeprazole and omeprazole are mainly in the following aspects: 1. Different potency, omeprazole belongs to the first generation of proton pump inhibitors, the acid inhibiting effect is not as strong as rabeprazole, rabeprazole belongs to the third generation of proton pump inhibitors, the effect of inhibiting gastric acid secretion is faster and stronger, the duration of effect is longer than omeprazole. 2. Different indications, omeprazole is used for gastroduodenal ulcers, stress ulcers, The side effects of omeprazole are mainly gastrointestinal reactions, such as nausea, diarrhea, epigastric pain, etc. The serious adverse reactions of rabeprazole are shock, cytopenia, hemolytic anemia, etc. 4. Interactions are different. There are more interactions between omeprazole and drugs, while there are fewer interactions for rabeprazole.