Patients: 1. Patients with multiple myeloma are immunocompromised and poorly tolerant of chemotherapy. Some scholars believe that early treatment can stop the progression of the disease and reduce the destruction of vertebrae, while others suggest that treatment is only needed when patients develop increased serum or urine M protein, anemia, hypercalcemia, osteolytic lesions, renal insufficiency, fractures, or extramedullary plasmacytoma. Can you describe the current progress in the treatment of this disease? 2. Will the success of M3 for leukemia induction differentiation therapy be used to induce other types of acute non-gonorrhea, acute gonorrhea, and even all tumors in the future? Thank you! However, in our current situation, once multiple myeloma is diagnosed, according to our own view, we think it is stable and the current situation is stable, so we can continue to observe it, but it is often difficult for patients and their families to accept it. Therefore, in our country, once multiple myeloma is diagnosed, almost all patients start treatment without waiting and observation.