The prognosis of highly differentiated hepatocellular carcinoma in liver cancer is relatively ideal, but according to the disease stage, liver cancer treatment is generally divided into five means, as follows: 1. surgical resection: it is a treatment method with the best prognosis at present; 2. radiotherapy; 3. many patients are not suitable for radiotherapy, at this time involving advanced tumors, systemic chemotherapy is usually administered, but systemic chemotherapy needs to consider the patient’s tolerance and indications; 4, Molecular targeted therapy and immunotherapy: used for advanced tumors, even highly differentiated liver cancer is aggressive and metastasis can occur. Molecular targeted therapy and immunotherapy in late stage is a good systemic therapy with far lower toxic side effects than systemic chemotherapy; 5. Minimally invasive therapy: the most commonly used minimally invasive therapy includes interventional therapy, i.e. TACE; ablation therapy can also be performed, and the most commonly used ablation therapy in clinical practice includes radiofrequency ablation and microwave ablation.