Toxemia (also known as poisoning or autointoxication) occurs when toxic substances that have not been excreted from the body begin to leach into the blood, lymph nodules and other body tissues. The body realizes that it must remedy the situation immediately, so it begins a full detoxification in an attempt to cleanse itself and stay healthy. Two diagnostic signs may occur when toxemia occurs: first, the body shows warning signs of more discomfort; second, the body loses further energy. If you are still working late at this time, or under a lot of stress, or not getting enough rest or sleep (all of which deplete energy heavily), the symptoms of fatigue and sleepiness will become more and more pronounced. When toxemia has progressed to the point where toxins must be removed, the disease moves to the next stage. There is a very typical and common signal that tells us unmistakably that toxins have accumulated to a level where they must be removed or the body will suffer. This signal appears in the second stage and also in all subsequent stages. It is the most obvious evidence that the body is trying to remove toxins on its own. Metabolism consists of both the absorption of nutrients and the elimination of waste (toxins). When toxins accumulate to a level that is too much for the body to handle and cannot be removed without special changes (such as a fever), it is necessary to rely on heat to speed up detoxification. Heat acts as a catalyst, causing toxins to liquefy and enter the bloodstream, where they are then transported to the various detoxification organs (intestines, bladder, lungs, and skin), from which they are ultimately excreted.