Azithromycin in the first month of pregnancy should strengthen the labor and delivery examination and pay attention to the development of the fetus. Azithromycin is mainly used for pharyngitis, tonsillitis and pneumonia caused by bacterial infections. Azithromycin is classified as a class B drug in the pregnancy classification, which means that it has not been shown to be dangerous to the fetus in animal reproduction tests, but no adequate and well-controlled studies have been done on pregnant women. Pregnancy category B drugs are generally considered relatively safe for pregnant women and fetuses. With azithromycin, it is recommended to intensify labor and delivery testing with NT ultrasound at 12 weeks of gestation and fetal systemic ultrasound screening at 20 to 24 weeks of gestation to check for fetal anomalies. Caution is needed when using medications in early pregnancy and consultation with a physician is recommended.