Polyethylene glycol is mainly used for the treatment of functional constipation, long-term use of the drug is bound to affect the body’s metabolism, body functions and some adverse reactions. 1. Long-term use of polyethylene glycol in the intestine can increase osmotic pressure to absorb water so as to soften the feces, but the human body will have electrolyte disorders, thus affecting gastrointestinal dysfunction, and then diarrhea, nausea, flatulence, and anal discomfort and other symptoms. 2. A few patients may have allergic reactions such as hives, runny nose, dermatitis, etc., and in severe cases, shock may even occur. But after stopping the drug, these symptoms will disappear. So you need to choose the dose under the guidance of the doctor. 3. It is worth noting, however, that it should be contraindicated for patients with abnormal intestinal motility or intestinal obstruction, which may not only cause intestinal perforation, intestinal necrosis, but also may cause significant gastric retention. Gastric retention can cause damage to the gastric mucosa, that is, it can cause gastric mucosal congestion and edema, and if it lasts for a long time, it can also cause mucosal erosion.