Three plus signs for hepatitis B depends on which three are plus signs. Generally, three plus signs in the five hepatitis B items means that there are three positive items, which may be major or minor triplets. Either way, it will be accompanied by a positive surface antigen for hepatitis B. This is the first item, which indicates a state of hepatitis B virus infection. The major triple-positive condition is also accompanied by a positive hepatitis B core antibody and E antigen, while the minor triple-positive condition is accompanied by a positive hepatitis B E antibody and core antibody. The difference between them is that the amount of viral replication is higher in major triple-positive patients and slightly lower in minor triple-positive patients. If the three plus signs for hepatitis B do not refer to these three, but rather to positive hepatitis B surface antibodies with core and E antibodies, this is three antibody positivity. The antibodies are not obtained by direct replication of the hepatitis B virus, but are produced by the body’s immune system, so this three plus condition is generally not a current state of infection, but simply a previous infection.