Leflunomide generally refers to leflunomide tablets, it is recommended to take vaccination 3~7 days after stopping leflunomide tablets, leflunomide tablets have adverse reactions and contraindications. Leflunomide tablets is a kind of drug for the treatment of rheumatoid arthritis, it belongs to the immunosuppressant, taking leflunomide tablets during the vaccine, may have an impact on the function of the body’s immune system, immune cells produce antibodies will be reduced, affecting the vaccine to play the protective effect. It is recommended to stop taking Leflunomide tablets for 3~7 days before vaccination. During the administration of Leflunomide Tablets, hair loss, itching, skin rash and other discomforts may occur. Leflunomide Tablets are contraindicated for those who are allergic to Leflunomide and its metabolites, and for patients with severe hepatic impairment, pregnant women and lactating women. How long to stop taking Leflunomide tablets for vaccination should be judged by a professional doctor, and the daily use of Leflunomide tablets should be carried out under the guidance of a doctor.