Hepatitis B virus dna belongs to the genetic material of hepatitis B virus, and hepatitis B surface antigen is the protein shell of hepatitis B virus, and the difference between the two is mainly the material difference. Hepatitis B virus dna is the genetic material of hepatitis B virus, and its dna replication is carried out in accordance with the principle of base complementary pairing, and the general load of hepatitis B virus dna is related to the replication level of hepatitis B virus, and the more dna load, the higher the degree of replication, which indicates that the hepatitis B virus is replicating actively in the body. Hepatitis B surface antigen is a protein shell on the surface of hepatitis B. Hepatitis B surface antigen usually also reflects how actively the hepatitis B virus is replicating in the body; if the virus is actively replicating, the level of hepatitis B surface antigen is high and more infectious. Hepatitis B virus dna and Hepatitis B surface antigen both reflect how actively the Hepatitis B virus is replicating in the body, and the more active the virus is, the higher the level of both, and the more contagious it is. When the test found that the level of hepatitis B virus dna and hepatitis B surface antigen is elevated, it is recommended to consult a doctor in time and carry out targeted treatment under the guidance of the doctor.