Thick and hard calluses on both sides of the heel are considered to be related to excessive walking, metatarsal warts, tinea pedis and other factors. It is recommended to pay attention to daily care, soften the cornea, anti-fungal drugs, if necessary, through surgical treatment. 1. Walking too much: usually walk too much, local long-term extrusion, friction, heel may form callus. It is recommended to often soak your feet in warm water, and use a file to remove the local callus layer by layer. However, pay attention to the care of the skin to avoid skin damage. Salicylic acid ointment and compound benzoic acid ointment can also be given to apply locally, which has a certain effect on softening calluses. 2. metatarsal warts: metatarsal warts are caused by human papillomavirus infection, after the latent period of viral proliferation, resulting in localized hyperkeratosis, and pressure with the hand may trigger pain. It can be used externally with imiquimod cream, which has an immunomodulatory effect. If multiple persistent plantar warts, systemic or local injection of interferon can be used to assist treatment. If the warts are large, they can be surgically removed. 3. Tinea pedis: Tinea pedis is caused by fungal infections, such as keratosis pilaris that may lead to thickening of the lesions. Keratolytic agents such as salicylic acid and compound benzene sulfonic acid ointment can be given to soften the skin. With antifungal drugs, such as tretinoin econazole cream, ketoconazole cream, compound bifonazole solution, terbinafine hydrochloride tablets, Butenafine cream, etc., have the effect of inhibiting or killing fungi. It is recommended to pay attention to personal cleanliness and hygiene, often change shoes and socks, and take shoes and socks to the sun. It is recommended that the patient go to the dermatology department of the hospital in time to clarify the cause, and then follow the doctor’s instructions to give treatment.