Toothache during breastfeeding is usually a case of acute pulpitis or acute apical tooth infection. Pulpitis and apical tooth infection are usually a mixture of Staphylococcus aureus, Streptococcus and anaerobic bacteria. For anaerobic infections, metronidazole, tinidazole or ornidazole tablets are very effective in treatment. Pain medications can be taken orally with ibuprofen capsules or gaucamycin. However, for breastfeeding women, these drugs are contraindicated and semi-synthetic penicillin broad-spectrum antibacterial drugs such as amoxicillin, meloxicillin or first- or second-generation cephalosporins such as cefadroxil capsules can be given orally. These drugs should be used only after weighing the pros and cons, that is, they should be considered only when the benefits of treatment outweigh the disadvantages. The best way is to go to the endodontics department for further examination to see if the pain can be relieved by means of dental treatment, and for teeth that have retention value, root canal treatment can be considered. Root canal treatment is generally divided into 3 steps: root canal preparation, root canal disinfection and root canal filling. Teeth that do not have any retention value may be considered for extraction.