Hepatitis B patients with weak legs may be related to the condition of hepatitis B itself or non-hepatitis B causes. On the one hand, chronic hepatitis B virus infection can cause fatigue symptoms, therefore, it is recommended that hepatitis B patients review relevant indicators, such as hepatitis B five, hepatitis B virus DNA, etc., and start antiviral treatment at the right time to control the progression of the disease, so that the symptoms of weak legs may be relieved with treatment. On the other hand, many chronic hepatitis B patients are asymptomatic unless they have progressed to uncompensated cirrhosis or have extrahepatic manifestations, so leg weakness may be caused by some non-hepatitis B causes, such as combining with other illnesses, recent colds, too much physical labor, malnutrition and so on, in this case, it is recommended that the patient actively find out the causes, and treat them according to the cause, so as to alleviate the symptom of leg weakness accordingly. If hepatitis B patients have related clinical manifestations, it should be noted that it may be a hint of aggravation of liver disease, at this time, we should go to the regular hospital to do the relevant examination, to clarify the cause of the disease in the doctor’s advice under medical treatment.