The causes of itching in the bend of two legs are many, common in daily life are inter-rub rash, atopic dermatitis, eczema, according to the patient’s specific performance for detailed analysis, determine the cause of the treatment. 1, inter-rub rash: commonly found in the bend of the legs, groin, armpits and other folds, folds of skin due to moisture, warmth, friction, secondary microbial infection caused by skin inflammatory diseases. The patient will feel itchy, can be accompanied by erythema, papules, clear borders, with bad odor, more topical drugs for treatment; 2, atopic dermatitis: is a chronic inflammatory skin disease associated with genetic allergies, common in children and adolescent groups, some people may also be sick in adulthood. Atopic dermatitis occurs in the elbow fossa, knee bend, the affected area is itchy and the skin is dry and mossy. Topical glucocorticoids can be used to control the symptoms, and in serious cases, the patient should go to the hospital dermatology department in time to choose a suitable treatment plan according to the overall situation, the drugs are mainly antihistamines, glucocorticoids, cyclosporine, biological agents, etc.; 3. Eczema: it may be related to genetics, allergies, changes in hormone levels and other factors, the patient’s skin at the bend of the leg will appear erythema, edema, blisters, papules, vesicles and oozing, accompanied by pruritus. Oral antihistamines and hormonal medications can be taken, and topical medications can be combined to stop the itching. It is also important to note that the itching in the bend of both legs should not be scratched frequently, try to wear loose, cotton clothing, and do a good job of skin cleaning.