Swollen eye blisters may be caused by physiological reasons such as drinking too much water before going to bed, or pathological reasons such as hypothyroidism, hypoproteinemia, glomerulonephritis, and so on. 1. Physiological causes: Swelling of eye blisters can occur due to sodium retention in the body caused by drinking too much water or consuming too much salt before going to bed, and the symptoms can be improved after improving living habits. 2. Pathologic causes: (1) Hypothyroidism: typical symptoms of patients can be seen as dull expression, slow reaction, facial and/or eyelid edema, dry and rough skin. (2) Hypoproteinemia: Hypoproteinemia may occur due to various liver diseases or malnutrition, etc., which may cause edema of the eye blisters. (3) Glomerulonephritis; Inflammatory edema with high tissue interstitial protein content, edema mostly starts from eyelids and face. There may also be other causes of puffy eye blisters, it is recommended that patients go to the regular hospital in a timely manner, improve the examination to clarify the cause of the disease, under the guidance of the doctor to give targeted treatment or treatment.