Treatment of extrapulmonary TB is also known as formal antituberculosis therapy. For most extrapulmonary TB, the regimen of choice is a quadruple anti-TB therapy of rifampin, isoniazid, ethambutol, and pyrazinamide. For a small percentage of extrapulmonary TB, such as tuberculous meningitis, the regimen may be different, requiring a drug that easily crosses the blood-brain barrier and a large amount of isoniazid, usually about 0.9-1.2g. For patients with severe disease, anti-tuberculosis treatment with linezolid is required. The treatment course is long, usually taking about 1 to 1.5 years, and attention needs to be paid to monitoring changes in the cerebrospinal fluid during treatment to determine the efficacy.