Senna leaf, also known as bubble bamboo leaves, laxative leaves. Taste sweet, bitter, cold, to the large intestine meridian, with diarrhea heat stagnation, laxative, diuretic effect, the main treatment of gastrointestinal fever, food stagnation, chest and abdominal distension, ascites, constipation. It is mainly used in the treatment of gastrointestinal bleeding, chronic renal failure, epidemic hemorrhagic fever, constipation, acute pancreatitis, toxic intestinal paralysis before and after internal, surgical and gynecological operations, and lumbar and abdominal X-rays, and intestinal preparations before surgery. However, because of its serious adverse reactions, clinical application is subject to certain restrictions, and requires strict control of its dosage. Common clinical adverse reactions include: 1, addiction: long-term use of senna constipation patients will appear withdrawal symptoms when discontinued, manifested as distress, insomnia, anxiety, general malaise, or even pain or ants, pupil dilatation, hot and flushed face, anorexia, fever, yawning, breathing faster, increased blood pressure, weight loss, etc.. 2, malignant changes in blood pressure: elderly patients taking senna may have headache and frequent vomiting, blood pressure rise or fall dramatically, or even shock, stop taking and symptomatic treatment can be restored. 3.Neurological toxic reaction: manifested as facial numbness, dizziness, incontinence, itching, trigeminal nerve distribution area may have varying degrees of pain loss. 4.Gastrointestinal hemorrhage: patients show severe pain in the upper abdomen, vomiting coffee-colored liquid and black stool. Jaundice: manifested as dizziness, fatigue and weakness, fever, yellow urine, yellow sclera, hepatomegaly, splenomegaly, decreased hemoglobin, and significantly elevated urobilinogen. 6.Others：such as pelvic organ congestion.