1. Why constipation? Neurosurgical coma patients and patients with recurrent stress ulcers are usually fasted with water, and most of the patients are also accompanied by different degrees of increased intracranial pressure. Increased intracranial pressure often causes nausea and vomiting, as well as postoperative cerebral edema and incision pain, resulting in loss of appetite, low intake and water intake, and secondly, after applying a large number of diuretic and dehydrating drugs, the body is in a state of dehydration, and the amount of water in the intestines decreases, which causes constipation in the gastrointestinal tract. The lack of sufficient food stimulates the peristalsis to decrease, causing constipation. Hu Yongzhen, Department of Neurosurgery, First Hospital of Qiqihar City, patients in coma, heavy craniocerebral injury, cerebral hemorrhage, cerebral disease resulting in hemiplegia limb dysfunction, spinal cord lesions, etc., due to the long time in bed, unable to move independently, resulting in gastrointestinal peristalsis slowing down and function, which is the main cause of constipation. 2. How to deal with it? Eat bananas, eat garlic, drink honey … everyone has become an expert, reliable or not, it is difficult to say, some really reliable, some results in general. Our specific specific measures: take senna leaves 5-10g, soak in boiling water and let it cool and drink, twice a day, stool out after stopping or reduce the number of applications. 3, why use senna? Senna belongs to contact laxative, can increase the frequency of defecation, soften the feces, increase the amount of defecation, a few hours after the administration of drugs, you can discharge soft, semi-fluid feces. 4. What are the types of laxative drugs? a Lubricating laxatives make it easier for stool to pass through the bowel. The most commonly used is mineral oil (e.g. liquid paraffin). b Irritant laxatives induce contraction of intestinal smooth muscle and promote peristalsis. Common ones are Stool Stopper and Senna. These laxatives sometimes cause abdominal cramps and it remains to be investigated whether long-term use can cause permanent damage to the intestinal wall. c Osmotic laxatives increase the osmotic pressure in the intestinal lumen, increasing the amount of water in the lumen and facilitating fecal elimination. Common ones include polyethylene glycol, sorbitol, lactulose and salt laxatives (including sodium phosphate and magnesium preparations). Osmotic laxatives are very effective, but overuse may lead to water-electrolyte disturbances.