The presence of 4C nodes in the breast suggests that the nodes are more likely to be malignant and surgical management should be considered. More than half of the 4C breast nodules are malignant. Clinically, mastectomy is usually used to remove the nodule first, and frozen pathologic examination of the nodule is performed during the operation to clarify the nature of the nodule, and the subsequent surgical procedure is determined according to the nature of the nodule. If the nodule is benign, the incision can be closed and the mastectomy can be completed; if the nodule is malignant, radical mastectomy may be required and axillary lymph node dissection may be necessary according to the patient’s condition. As 4C nodes of breast cancer have a higher possibility of malignancy, it is recommended that patients should seek medical treatment as early as possible to avoid the progression of the disease and the adverse consequences.