If left untreated, Macrognathia may lead to precocious puberty in boys and masculinization of girls. Girls with gigantism may be born with an enlarged clitoris, which gradually enlarges to resemble a boy’s penis, and labia majora, which resemble a boy’s scrotum, but have no testicles. In boys, the penis is slightly larger than normal at birth, and symptoms of precocious puberty begin to appear around the age of half a year, and become more pronounced at the age of four or five, mainly in the form of a rapidly enlarging penis, enlarged scrotum and enlarged prostate gland. If patients with macropubic syndrome are not treated in time, it may not only affect the normal development of the reproductive organs, but also bring serious psychological burden to the patients in their life, it is recommended to go to regular hospitals in time for examination and early treatment.