Taking tuberculosis drugs (such as isoniazid, rifampicin, etc.) with severe body pain may be caused by tuberculosis bacilli invading the organism or pharmacologic injury, or it may be caused by elevated uric acid levels. 1. Mycobacterium tuberculosis invades the organism: if Mycobacterium tuberculosis invades the organism and causes an inflammatory reaction, severe body pain may occur when taking tuberculosis medicine. 2. Pharmacological damage: If you take anti-tuberculosis drugs and experience severe pain, it may be due to pharmacological damage caused by the side effects of the drugs. This is because anti-tuberculosis drugs have certain toxicity, such as hepatotoxicity, nephrotoxicity, etc., which may cause drug-related liver injury or kidney injury, thus causing severe pain in some parts of the body. 3. Elevated uric acid level: If a TB patient takes anti-tuberculosis drugs, such as pyrazinamide, resulting in elevated uric acid levels, it may also cause severe pain. If you are taking tuberculosis medication for severe pain, it is recommended that you go to the hospital as soon as possible for a review and provide timely feedback to your attending physician to find the cause of the severe pain and then take targeted treatment measures.