Nail seam itching mainly has the following possibilities: First, fungal infection, fungal infection will appear localized rash itching, erythema, blisters, this situation needs to go to the hospital to do fungal immunofluorescence examination to confirm the existence of fungal infection, if confirmed the need for antifungal treatment. Second, eczema dermatitis, eczema is prone to localized itching, hypersensitivity reactions. This time should check the allergens, usually must pay attention to moisturizing to prevent dry cracks, after washing hands need to be coated with petroleum jelly moisturizing further moisturizing. Third, contact dermatitis, contact with the new environment or chemical substances, there will be localized itching, this case must check the cause, avoid contact with infected substances, do not repeat the stimulation, if necessary, you can use boric acid to water 1:3 wet compresses or topical application of small doses of Eloxon.