HPV16-positive is an infection with human papillomavirus type 16, which is usually contracted from sexual transmission, indirect contact and mother-to-child transmission. 1. Sexual transmission: Both men and women who have HPV16 infection in the genital mucosa may infect each other if they have unprotected sex, and the probability of transmission is relatively high. 2. Indirect contact: If a female patient is physically weak and her immune function is relatively poor, she may be infected after close contact with an HPV16-positive patient or after sharing public goods such as toilet bowls and bath towels. 3. Mother-to-child transmission: If the mother is HPV16-positive, the newborn may be infected by HPV during delivery through the birth canal. It is recommended that patients actively take preventive measures in their lives. If diagnosed as HPV 16 positive, they should seek medical treatment in time and under the guidance of the doctor to carry out reasonable treatment.