Symptoms of gallbladder cancer in late stage mainly include digestive system symptoms such as nausea and abdominal pain, peripheral tissue invasion symptoms such as jaundice and back pain, distant metastasis symptoms such as poor appetite and cough, and systemic symptoms such as fever and emaciation. Gallbladder cancer is the most common malignant tumor of gallbladder. There is no specific clinical manifestation or only symptoms of chronic cholecystitis in early stage, so early diagnosis is very difficult, and once there is persistent pain in epigastric area, jaundice and other lesions, the disease has already reached the advanced stage. Its late symptoms are mainly: 1. symptoms of digestive system mainly include obvious pain in right upper abdomen, nausea and vomiting, diarrhea, abdominal distension, indigestion and so on. 2. gallbladder cancer infringes on liver cells or bile duct cells or presses on bile ducts, etc., leading to jaundice, often accompanied by itching of skin and white clay-like stools, etc. Some patients infringe on pancreas causing severe abdominal pain or back pain, etc. 3. Metastatic symptoms: invasion of liver causes poor appetite, abdominal pain in the liver area, etc. Metastatic lungs cause coughing and chest pain, etc. Systemic symptoms include fever, chest pain and fever. 4. Systemic symptoms include fever, emaciation, fatigue, dizziness, etc. For patients suspected or diagnosed with gallbladder cancer, it is recommended to go to regular hospitals for comprehensive assessment of the condition, follow the doctor’s instructions to cooperate with the treatment, and choose the appropriate treatment plan to avoid delaying the condition.