Whether hepatitis B virus amount reaches 4 times square needs to take medication depends on liver function and liver ultrasound, if liver function is abnormal or liver has histological damage needs to be treated, if both tests are normal, no treatment is needed for the time being. 1. No treatment is needed: Generally, the normal value of hepatitis B virus DNA quantification is 3 times square. Therefore, a Hepatitis B viral load of 4 times square is an excessive viral load. In the case of normal liver function and no liver damage, there is no need to receive treatment. 2. Need for treatment: If the hepatitis B viral load reaches 4 times square with abnormal liver function or histologic damage to the liver, or even cirrhosis, this situation needs to be treated. Currently, the first-line drugs for treating hepatitis B include entecavir as well as tenofovir. In addition, Hepatitis B is a dangerous disease, and once diagnosed, patients need to actively seek treatment under the guidance of a specialist and undergo regular review.