Oral cancer with neck lymphatic metastasis usually belongs to the middle and late stage of cancer, which can be treated by surgery, radiotherapy, chemotherapy and targeted therapy. Oral cancer with neck lymph node metastasis often represents that the condition has entered the middle or late stage of cancer, which can be treated by preoperative radiotherapy to reduce the number of tumor cells and shrink the tumor at the same time; then surgical resection of local lesions and neck lymphatic dissection can be performed. There may be tumor residues at the surgical margins of oral cancer, so adjuvant radiotherapy is needed to kill the residual tumor cells. In addition, chemotherapy and targeted therapy can be supplemented. Chemotherapy can choose methotrexate, fluorouracil, bleomycin, cisplatin, vincristine, paclitaxel and other drugs, and targeted therapy can choose cetuximab and other drugs. If oral cancer with neck lymph node metastasis is diagnosed, please follow the doctor’s instruction for treatment.