Physiological causes of frequent poor appetite and loss of appetite to be considered are lack of exercise and pregnancy. Pathological causes can be seen in diseases such as gastritis, hepatitis, cholecystitis, dyspepsia, renal insufficiency, and cardiac insufficiency. Insufficient exercise, the body consumes less energy, and with the slowing down of gastrointestinal motility, it is easy to have a poor appetite. During pregnancy reaction, the sudden increase of progesterone can affect the digestive tract with symptoms such as nausea, vomiting and loss of appetite. In gastritis indigestion, the gas in the stomach tends to increase causing the stomach to dilate and stimulating the nerves in the stomach wall reducing appetite. Hepatitis and cholecystitis, which can affect the digestion and absorption of fatty foods, can also have an increase in serum transaminases, stimulating the central hunger center to produce a feeling of fullness and reduce appetite. Cardiac insufficiency can lead to liver stasis and digestive tract stasis, affecting digestion and absorption. Renal insufficiency can have accumulation of metabolites such as uric acid and creatinine, which stimulates the hunger center in the brain and affects appetite.