Lao Wang’s case Lao Wang, 62 years old, six months ago due to swelling of the lower limbs and increased foam in the urine, when he came to the hospital, the examination found that the urine protein was 3+, blood creatinine reached 187umol/L, and ultrasound found that both kidneys had enhanced cortical echogenicity, which led to the diagnosis of chronic kidney disease stage 3. Doctors told him that the treatment of chronic renal insufficiency can only do to slow down the rate of renal function decline, and suggested him to strictly control blood pressure, low protein, high quality protein diet, and other renal drugs to protect the residual renal function. Last week, the pale old Wang came to the clinic again with the help of his family members, with obvious swelling, low urine output, accompanied by nausea, vomiting, chest tightness and shortness of breath, and the blood biochemistry of the emergency examination suggested that the blood creatinine reached 1210umol/L, and the blood pigment only 6g/dl, and there was a serious hyperkalemia, with the blood potassium amounting to 7.3mmol/L. The doctor said that the old Wang had already progressed to the end-stage uremia and was given emergency hemodialysis because of the obvious hyperkalemia. emergency hemodialysis was given. In just half a year’s time, Lao Wang has progressed from the early stage of chronic renal failure to the end-stage, the speed of disease development is much faster than expected, the doctor was puzzled, and after carefully asking Lao Wang’s family members, he realized that he had progressed to the end-stage uremia. Originally, six months ago in the hospital, the doctor said that there is no special drug can bring down the blood creatinine, the disease will slowly progress, and finally may develop into uremia. Hear may become uremia, the old king scared to death, went home and asked around where there are prescriptions to treat renal insufficiency, and then in a charlatan doctor there opened a Chinese medicine prescription. Originally there is no obvious discomfort, after eating the prescription for a few months, the amount of urine gradually reduced, and there is a significant weakness, loss of appetite and so on. Sometimes, Chinese medicine prescription not only can’t cure big diseases, may have obvious nephrotoxicity Kidney is an important excretory organ of the human body, discharging a large number of metabolites in the body. At the same time, renal blood flow is particularly rich, accounting for 20% to 25% of the cardiac output, and thus a large number of drugs into the body after which a large number of them can enter the kidneys; kidneys in the excretion of metabolic products, will be the concentration of substances in the bloodstream, resulting in the role of the renal tubules on the surface of the excretory concentration of the high, such as water-soluble drugs in the urine, the concentration of which can be up to 100 times the concentration of blood, and in addition, the proximal tubule of a variety of drugs with In addition, the proximal tubule has secretion and reabsorption effects on a variety of drugs, which also increases the chances of drug interaction with renal tubular epithelial cells. Due to the anatomical and physiological characteristics of the kidney itself, if the use of drugs is not careful, when the type of drugs, dosage and time of use are not appropriate, the renal function is easily damaged. From the Chinese medicine prescription provided by Lao Wang’s family, the hospital pharmacist found that it contained Mutong. Although the Chinese medicine Mutong has the effect of diuretic and drenching, it has clear nephrotoxicity to the kidneys because it contains aristolochic acid, inducing aristolochic acid nephropathy, which manifests itself as acute renal failure in severe cases. It is particularly dangerous for patients with pre-existing kidney disease and can lead to rapid deterioration of chronic kidney disease. Chinese medicine is the treasure of the Chinese nation, however, there is no need to avoid, part of the Chinese medicine ingredients do exist obvious liver, kidney toxicity. Therefore, if you want to take Chinese medicine, you must go to a regular hospital and use it under the guidance of a Chinese medicine practitioner. In addition to the so-called Chinese medicine prescriptions, some western medicines also have obvious nephrotoxicity, such as certain painkillers, aminoglycoside antibiotics, antitumor drugs, radiological examinations and interventional procedures using contrast agents, and so on, and even a long time to take Omeprazole and other proton pump inhibitor class of gastric drugs, may be a serious damage to the kidneys. Therefore, patients with kidney disease must be careful with medication, to understand the possible nephrotoxicity of drugs, do not blindly take drugs, increase the dose of drugs on their own, should be under the guidance of a doctor to use medication, in order to prevent the damage of drugs to the kidneys.