Most patients taking pirempanel have only mild side effects, although patients are highly individualized and the degree of manifestation varies. The most serious adverse reactions are severe psychiatric and behavioral reactions and suicidal behavior and ideation. Pirempanel is a third-generation antiepileptic medication, and the rate of adverse reactions to Pirempanel is small compared to the first two generations of antiepileptic medications. The most common adverse reactions to pirempanel are dizziness and somnolence. Serious adverse reactions are severe psychiatric and behavioral reactions such as paranoia, euphoria, belligerence, agitation, anger, altered mental status, disorientation or confusion and suicidal behavior and ideation. After taking the drug if there are uncomfortable symptoms, can not adjust the dose of drugs or unauthorized stop changing other drugs, must go to the hospital neurology department consultation, under the guidance of professional doctors to adjust the drug.