Treatment of ankylosing spondylitis, as follows: 1, choose non-pharmacological treatment, that is, general treatment, to functional exercise, but also to patient education, so that patients understand the disease. Then functional exercise, mainly for the exercise of lumbar muscles, to maintain joint function so that they do not deform; 2, drugs, non-steroidal anti-inflammatory drugs for the familiar loxoprofen, fenbendazole, furosemide, ciloleucine and other drugs, as well as tumor necrosis factor-alpha antagonists, including fusion proteins and monoclonal antibodies are among the first-line drugs. For peripheral spondyloarthropathies and ankylosing spondylitis, traditional palliative medications such as methotrexate and salbutamol are also available. For combined ophthalmoplegia, uveitis and severe peripheral arthritis, glucocorticoid local injection therapy can be tried. 3. For patients with late severe disease, resulting in hip involvement and spinal deformity, surgical treatment can be resorted to correct the deformity and restore joint function.