High serum AST/ALT ratio, if it is not combined with the elevation of glutamic oxaloacetic aminotransferase and glutamic alanine aminotransferase, this index has no clear clinical significance, and it is recommended to follow up and observe; if it is combined with the obvious elevation of aminotransferase, it is often suggestive of cirrhosis of the liver, active hepatitis, hepatocellular carcinoma, and other serious diseases. AST is the enzyme that is found in the mitochondria of hepatocytes, while ALT is the enzyme that is found in the cytoplasm of hepatocytes. When hepatocyte damage is mild, ALT is the first to be elevated. If the mitochondria remain intact, AST may be normal or only mildly elevated, and only when inflammation worsens, structural damage to the hepatocyte intensifies, and the mitochondria are destroyed, does AST become significantly elevated. The ratio of AST/ALT is commonly used in clinical practice to reflect the damage of hepatocytes, and can be used as an indicator to observe the development and prognosis of liver disease. When liver cirrhosis, chronic active hepatitis, liver cancer, liver cells are severely damaged, which will lead to a significant increase in AST and ALT, and AST/ALT increases, AST/ALT decreases are common in the early stage of acute hepatitis and mild chronic hepatitis. Therefore, it is recommended that patients should seek medical treatment in time to determine the cause and severity of the disease in combination with symptoms and aminotransferase levels.