Whether hepatitis B core antibody and e antibody positive is important or not can’t be generalized, it should also be evaluated according to other test results, as well as viral replication, patient’s specific symptoms and other comprehensive factors. 1. Not serious: Hepatitis B core antibody and e antibody positive, other test results negative body does not have any uncomfortable symptoms, liver function is normal, generally indicates that the body has been infected with hepatitis B, has been cured is not important. But we need to exclude the recovery period of acute infection, in this case, the surface antigen of hepatitis B has the possibility of re-positive. 2. Possible serious situation: if hepatitis B 5 indicators, in addition to hepatitis B core antibody and e antibody positive, at the same time, hepatitis B surface antigen positive, it means that it belongs to hepatitis B minor triple sun, infectious, and will cause liver damage, especially with liver function abnormalities, as well as active replication of the virus in the body, or jaundice and other symptoms such as pain in the liver area and skin jaundice, we need to consult a doctor in time, for liver preservation and antiviral treatment. Hepatitis B core antibody and e antibody are positive, it is recommended to go to the hospital for further examination and follow the doctor’s instructions.