Ibuprofen is a non-steroidal anti-inflammatory and analgesic, used for the treatment of chronic painful diseases, and busulfan is a traditional Chinese medicine dosage form with anti-inflammatory and anti-swelling effects, mainly used for the treatment of septic diseases such as boils and carbuncles. It is suggested that it is best not to take them together orally at the same time, because the drug interactions between them are not very clear, and taking them together may cause rash, itching and more serious allergic reactions, etc.; they both have digestive system adverse reactions, such as nausea, vomiting, etc., and taking them together may increase gastrointestinal irritation symptoms, etc.