Coughing worse after taking medication is related to whether the medication taken is symptomatic, whether the dosage and duration of treatment are sufficient, and whether there is a new disease causing the cough. Common causes of cough are acute bronchitis, cough variant asthma, etc. Different causes, treatments and medications are also different. 1. Causes of cough (1) Acute bronchitis: mostly caused by viral infections, frequent and severe coughing can be short-term use of cough suppressants, such as dextromethorphan, etc., accompanied by thick sputum is not easy to cough up, can be used to dissolve sputum, such as aminoglutethimide hydrochloride. If it is clearly associated with mycoplasma and chlamydia, macrolide antibiotics such as azithromycin can be used. (2) Cough variant asthma: commonly used drugs are glucocorticosteroids such as prednisone, budesonide, etc., bronchodilators such as terbutaline. 2. Dosage and duration of treatment: when the dosage and duration of treatment are not enough, the cough will be aggravated even after taking the medicine, it is recommended to adjust the dosage and duration of treatment under the guidance of the doctor in a timely manner. 3. There are other diseases that cause coughing: you should improve the relevant examinations in a timely manner to clarify the cause of the disease and standardize the treatment under the guidance of the doctor. If the cough is worse after taking the medicine, it is recommended to go to the hospital as soon as possible to find out the cause and standardize the treatment. All of the above drugs should be used under the guidance of a doctor, avoid self-medication.