Changing tenofovir to entecavir is generally not risky, but it is recommended to consider switching medications when indicated and to consult a physician before switching medications, do not change medications on your own to avoid adverse consequences. Tenofovir and entecavir are both antiviral drugs that inhibit the replication of the hepatitis B virus, and can be used to treat hepatitis B. Changing tenofovir to entecavir is generally not risky, and if tenofovir is effective, it is not recommended that patients change medications at will. For hepatitis B treatment, Tenofovir needs to be taken orally for a long period of time in order to better inhibit viral replication, and if other drugs are changed arbitrarily, it may lead to drug resistance in patients, making the choice of drugs limited. If patients develop renal impairment, severe gastrointestinal reactions, emergence of drug resistance, and hypophosphatemic bone disease while taking tenofovir, they can consider switching to entecavir. However, in the process of switching medication, it should be carried out under the guidance of the doctor, and cooperate with the doctor to improve the quantification of hepatitis B virus DNA, drug resistance genes, liver function and other tests, and then consider adjusting the use of medication after a comprehensive assessment. If patients have the need to change medication, they should do so under the guidance of a doctor, and should not change medication on their own to avoid adverse effects.