There is no such thing as the best Hepatitis B vaccine, but rather it needs to be administered in strict accordance with the vaccination program in order to achieve the maximum protective effect. Hepatitis B vaccine, as a special preparation for the prevention of hepatitis B, will stimulate the body’s immune system to produce corresponding antibodies after vaccination, which can effectively prevent hepatitis B virus infection. No matter newborn babies, children or normal adults, they need to be vaccinated according to the program of “0 month, 1 month, 6 months” in order to maintain the antibody at a high level. Hepatitis B vaccine still has a certain period of time after vaccination and cannot achieve the effect of lifelong immunization, and the specific period of time has individual differences. In order to ensure that the protective effect of hepatitis B antibody reaches the optimal level, it is necessary to have regular checkups and to carry out booster vaccination when appropriate. In order to effectively prevent the spread of hepatitis B virus, we must choose regular medical institutions and follow the regular procedures of hepatitis B vaccination.