Diabetes mellitus with diabetic nephropathy may cause microalbumin, when the blood glucose is lowered urine microalbumin is likely to be reduced. When diabetic patients have microalbumin, it is usually considered that diabetes mellitus may be complicated by diabetic nephropathy. At this time, in addition to the need for treatment of kidney disease should also do a good job of blood glucose management and monitoring, especially when the blood glucose control is good, it is possible to reverse albuminuria, but also to slow down and stop the further development of diabetic kidney disease. Therefore, when the blood sugar down after the urine microalbumin is likely to be reduced. Diabetic patients with urinary microalbumin should actively cooperate with doctors for treatment, which will help improve the prognosis.