Pre-excitation syndrome is more complex, depending on the condition, comorbidities and so on, the choice of drugs such as propafenone, amiodarone and so on. 1. Drugs for acute exacerbation (1) Pre-excitation syndrome with normal cardiac function: oral propafenone and other drugs can be chosen, but for those with obvious symptoms, intravenous drugs usually have a faster effect, and are more often used in the clinic. Close electrocardiogram and other tests are needed in the use of the drug, and the drug should be stopped after the tachycardia is relieved. (2) Pre-excitation syndrome combined with cardiac insufficiency: Oral amiodarone can be chosen for the same reason as above, and intravenous administration is more often recommended. If manifestations such as hypotension are present, electrical cardioversion is preferred. (3) Pre-excitation syndrome combined with atrial fibrillation or atrial flutter: it is recommended that electrical cardioversion is preferred for treatment, and drugs such as ibutilide can be chosen for those who are unable to undergo electrical cardioversion, but the use of drugs such as verapamil and diltiazem is prohibited. 2. Non-acute relapse prevention drugs: for those who cannot undergo radical surgical intervention, if the cardiac function is normal and there is no ischemic or structural heart disease, oral propafenone can be chosen; if there is severe organic heart disease, oral amiodarone is recommended. The eradication of preexcitation syndrome usually requires surgical intervention such as radiofrequency ablation. The use of the above medications needs to be under the supervision of a clinician; prompt hospitalization is recommended for the presence or suspicion of pre-excitation syndrome.