Patients with maxillary sinusitis should use sensitive antibiotics according to the results if bacterial culture and drug sensitivity tests are performed; if relevant tests are not performed, drugs such as amoxicillin clavulanate potassium and cefuroxime can be used empirically, and the medication should be adjusted according to changes in the condition. Maxillary sinusitis is an inflammation that occurs in the mucosa of the maxillary sinus, which can be caused by infection, allergy, trauma and other factors, and can also be related to a variety of factors such as mucosal cilia structure and dysfunction. In those with maxillary sinusitis caused by bacterial infection, if bacterial culture and drug sensitivity tests have been performed, sensitive antibiotics should be targeted, and if the relevant tests have not been performed, broad-spectrum antibiotics, such as amoxicillin clavulanate potassium, cefuroxime, and other medications, can be used. Often in the standardization of anti-infective treatment at the same time, the rational use of decongestants, such as 1% ephedrine nasal drops, or the use of loratadine to reduce local allergic reactions. After the onset of the disease should actively seek medical attention, after a clear diagnosis and etiology, follow the doctor’s instructions to standardize the use of drugs and treatment.