High triglycerides and high cholesterol have different definitions, different hazards and different treatments. 1. Different definitions: high triglyceride is mainly triglyceride level exceeding the normal range, while patients with high cholesterol have elevated cholesterol level, which also includes elevated LDL level and reduced HDL level. 2. Different hazards: Elevated triglycerides and elevated cholesterol both promote the progression of atherosclerosis, but when triglyceride levels rise significantly, it may also increase the risk of acute pancreatitis. 3. Different treatments: patients with elevated triglycerides need to be treated with beta-lipid-lowering drugs, commonly used drugs include fenofibrate, etc. patients with elevated cholesterol need to be treated with statins, commonly used drugs include atorvastatin calcium, etc. High triglycerides and high cholesterol are both called hyperlipidemia, which should be diagnosed and treated under the guidance of a physician and appropriate medication should be chosen.