Oxycodone hydrochloride tablets and morphine hydrochloride tablets are not recommended to take at the same time, it is recommended to choose a drug under the guidance of a doctor. Oxycodone hydrochloride tablets active ingredient is oxycodone, but also belongs to a morphine opioid agonist, and morphine hydrochloride tablets belong to the same class of drugs, the two taken at the same time may prolong the inhibitory effect of morphine, resulting in tolerance and dependence, which can cause respiratory difficulties, nerve disorders, muscle twitching and other conditions. Therefore, it is recommended that patients choose a morphine painkiller under the advice and guidance of a doctor, and use the medication in strict compliance with the doctor’s instructions, to avoid unauthorized abuse of drugs to prevent the body from experiencing other adverse reactions.