Tumor screening examination, infection-related examination and other examinations should be done before taking biological agents. 1. Tumor screening examination: Tumor screening such as liver, lung, gastrointestinal and prostate and other tumor indicators, if the patient suffers from malignant tumors before using biologics, it is not recommended to take biologics again, because biologics may have an effect on the treatment of malignant tumors. 2. Infection-related examination: screening for infection is necessary before using biologics, such as tuberculosis, hepatitis virus and chest CT examination, because the use of biologics for the treatment of tuberculosis and viral hepatitis may have a mutual influence on the treatment, affecting the therapeutic effect. 3. Other examination: routine examination is also necessary, such as blood routine, urine routine, liver and kidney function, electrocardiogram and so on, because some of the biologics have effects on heart, liver and kidney, so it is necessary to monitor the indicators. Before taking biological agents, we should do all the examinations to make clear whether it is suitable or not, and if there is any discomfort, we should consult the doctor in time so as not to lead to the progression of the disease.