Looking at the history of psoriasis drug treatment, from the mustard gas ointment, procaine closure and autologous blood therapy in the former Soviet Union studied in the 1950s in China; from leucovorin in the 1960s to ethylimine in the 1970s and ethylbis-morpholine in the 1980s, most drugs were eliminated either because of their insignificant efficacy or because of their large adverse reactions, which is similar to the international situation. When reviewing the history of psoriasis treatment, Fry (1988), a British scholar, mentioned that antipsoriasis drugs have been introduced in the past hundred years, but most of them were popular for a while, and many of them were either not effective or had serious side effects and were eliminated (such as heavy metals and anti-tumor drugs), while few of them were really safe and effective and withstood the test of time. According to foreign history, the most effective oral medication for psoriasis in the early years was arsenic (such as Fowler’s solution – potassium arsenite solution), followed by turpentine and spotted cypress; topical use included tincture of salicylic acid and alkaline bath to remove scales, as well as tar preparations, naphthol, muscimol and kochinin (chrysarobin, (used to be called insect repellent bean paste), etc. X-rays were used to treat psoriasis for about 50 years, starting in 1900. In 1916 Galewsky et al. synthesized dithranol for the treatment of psoriasis, and it is worth mentioning that in Chinese medical literature there are records of black bean oil slips for the treatment of skin diseases, and this preparation is less irritating than other tar preparations for psoriasis. alderson (1923) reported good results with ultraviolet light for psoriasis. 1953 In 1950, corticosteroids such as cortisone and hydrocortisone were introduced and began to be used for dermatological treatment, but they had little effect on psoriasis, as did topical hydrocortisone. In the 1950s the molecular structure of this hormone was altered to synthesize prednisone and trenbolone for oral administration, which showed moderate efficacy in psoriasis, but similar to other treatments, these drugs were only temporarily suppressed and the disease returned after discontinuation. These drugs could not be widely accepted because of the side effects of long-term corticosteroid therapy and rebound after discontinuation. By the early 1960s, further changes in the molecular structure of hormones introduced strong corticosteroid preparations such as fluphenazole and betamethasone 17 valerate effective in treating psoriasis, especially with encapsulation therapy that increased drug absorption, but by the late 1960s, people were more familiar with their side effects, long-term application caused skin atrophy, and large applications suppressed the pituitary-adrenal axis. stronger in the 1970s topical steroids such as clobetasol propionate were synthesized and their antipsoriatic effects were stronger, but the side effects remained the same as those of the potent corticosteroids. It seems clear now that such agents are not the panacea hoped for in the treatment of psoriasis, mainly because the side effects limit their long-term use. In addition, with continuous topical application, the effect decreases, i.e., the so-called rapid immunity (tachyphylaxis) occurs, and the responsiveness of the body gradually decreases. 1973 was the year when Tronnier and Schule first used topical psoralens plus UVA, and then Parish et al. reported good results with oral administration of this preparation plus high-intensity UVA for psoriasis (i.e., PUVA). The limitation, however, is that long-term application has the potential to be very effective. However, the limitation is that long-term application has the problem of skin cancer. In 1951 Gubner treated rheumatoid arthritis with the folic acid antagonist aminopterin (leucovorin, aminopterine) in a patient who also had psoriasis and found that the psoriatic lesions faded quickly. Then he used it to treat psoriasis and got good results. In the 1950s, including China, the treatment of psoriasis flourished, but its side effects, especially the occurrence of leukemia, was soon replaced by its derivative methotrexate (MTX), and by the 1960s MTX was widely used in the treatment of psoriasis, but it should be noted that it has the side effect of hepatotoxicity. (Kligman, 1998). In 1992, another new drug, acetylenic retinoid, tazarotene, was synthesized, showing its value in the treatment of psoriasis. In 1992, another new drug, acetylenic retinoid, tazarotene, was synthesized, showing its value in the treatment of psoriasis and prolonging remission. In 1988, Kragballe et al. first treated psoriasis with calcipotriol, which was effective in some patients, but not in others. Other drugs developed in the last 30 years for the treatment of psoriasis are cyclosporin (cyclosporin), which has an immunosuppressive effect, and the T-cell suppressing effect of cyclosporin is effective for psoriasis clearance; indeed, so far the drug has shown to be highly effective in the treatment of psoriasis, but the application may be limited by the side effects of nephrotoxicity and the risk of hypertension. Light therapy (narrow-spectrum UVB) has been effective for many patients in the last decade, but often this treatment is not sensitive after another relapse or as the number of treatments increases. As people become more stressed, the implementation of psychological interventions to treat patients has been effective for some patients. However, the above treatments and drugs, both domestic and foreign, are experimental treatments, and there are no definite and sure treatment drugs yet. And people are a whole, people and people, the environment, climate, their own habits and character are inseparable, a whole, everything is mutually reinforcing, and psoriasis patients’ own treatment is the most important, and the motherland medicine – Chinese medicine for psoriasis (pine skin ` and other names) also has a history of many years, dialectical treatment has good effect on the disease. Green, safe and effective treatment methods are preferred to Chinese medicine. Such as Chinese medicine, acupuncture, blood cutting, cupping, medicinal baths, etc. . If patients can recognize the importance of their own treatment and supplemented by the correct treatment plan, and use dialectical materialistic thinking to look at themselves and external things, looking for internal and external causes, ice skin like snow, skin like gelatin, blowing, peach blossom jade face, hands like catkins is not a dream.